Let's say, you are standing in front of a one of those party buttons that triggers a positing system between your current section of the level and the next. Let's say, you also know/expect the next section to be difficult.
Finally, let's say, the game decided to mock you by dropping an extra pill in your current section, which you cannot pick up because you are already carrying three pills and are (almost) full on health. What do you do?
A lot of people might opt for taking the extra pill, so it does not go to waste, even if they are only half a pip short on health.